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KMID : 0604520170430040281
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Journal of the Society of Cosmetic Scientists of Korea
2017 Volume.43 No. 4 p.281 ~ p.287
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Acceleration of DNCB-induced Early-apoptosis via Activation of Corticotropin Releasing Factor in the Hair Root of NC/Nga Mice
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Park Gun-Hyuk
Jang Eun-Young
Kim Seong-Bae
Han Eun-Young
Kim Yong-Ung
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Abstract
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Stress in skin plays a significant role in both the direct/indirect regulation of cellular processes occurring in hair, which in turn affect the hair cycle. However, experimental data regarding the effects of stress-related corticotropin releasing factor (CRF) released by stress on the apoptotic process involved in hair is limited. Therefore, we investigated the acceleration of early-stage apoptosis induced by atopy-related stress using a 2,4-dinitrochlorobenzene NC/Nga mice model. Expression of CRF, its related proteins, annexin V, and mitochondrial dysfunction were measured by immunohistochemical analyses. Atopic stress strongly stimulated stress hormones response, such as CRF and adrenocorticotropic hormone, in outer epithelial sheath of the hair. Moreover, its stress induced mitochondrial damage and early-stage apoptosis of cells in hair root. These findings suggest that hair damage due to apoptosis in atopy model is accelerated in a high CRF environment. Importantly, the effect of stress-related CRF on apoptosis processes involved in atopy dermatitis- related hair loss, suggests that the CRF-regulating development or maintenance materials may provide effective therapeutic strategies for hair health.
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KEYWORD
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atopy, corticotropin releasing factor, hair root, apoptosis
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